Robert Lefkowitz

An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser.

Robert J. Lefkowitz, M.D., is James B. Duke Professor of Medicine and Professor of Biochemistry at the Duke University Medical Center. He has been an Investigator of the Howard Hughes Medical Institute since 1976. Dr. Lefkowitz received a Bachelor's degree from Columbia College and an M.D. degree from Columbia University College of Physicians and Surgeons. After serving an internship and one ye...

Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel laureates in chemistry.

Those of us that had been hammering away in the field for 40 years or more cannot deny the excitement in learning that Brian Kobilka, a former postdoctoral fellow of Robert Lefkowitz, in collaboration with Roger Sunahara, had determined the structure of the agonist-bound β2-adrenergic receptor-Gs protein complex (1). To borrow a phrase from Henry Bourne, this is “the Big Enchilada” for the G pr...

Robert Insall

Robert Insall was born in London in 1965, into a family of architects, musicians and historians. To their great surprise, he was obviously scientifically inclined from an early age. He did a B.A. at Cambridge University, then stuck around in Cambridge for a Ph.D., where he got interested in Dictyostelium, followed by a postdoc in Johns Hopkins, where he got interested in chemotaxis and cell mov...

Robert Koch

Robert Dottin

We are investigating the signal transduction mechanisms by which extracellular hydrophilic hormones activate genes. We use Dictyostelium discoideum as a model eukaryote because it is relatively easy to perform reverse genetics on this organism and it is also capable of development. We had earlier shown that extracellular cAMP behaves as a hydrophilic